Our study aimed to estimated the incidence of KRAS and NRAS mutations (KRAS exons 2/3/4 and NRAS exons 2/3/4) in Moroccan population, to identify the clinicopathological characteristics of KRAS and NRAS gene mutations and to evaluate their prognosis value in colon cancer. The gene discussed is KRAS; the disease is malignant colon neoplasm.