Moreover, some of the genes with lower H3K27me3 mark on the gene body/enhancer regions following DHT treatment, like Cyp19a1 [78], Adamts15 [79] Casp7 [80], Erbb4 [81] and Lepr [82] have been reported to be elevated and/or associated with PCOS. The gene discussed is LEPR; the disease is polycystic ovary syndrome.