From the IHC of ki‐67, TRAF3, Cyclin D1, CDK4 and Bcl‐2 and TUNEL assay (Figure 7H), the results indicate that hypoxic EVs can facilitate growth by repressing the TRAF3 and promoting cell cycle transition (G0/G1 to S) and inhibit the apoptosis of CRC cells by elevating the Bcl‐2 in vivo. This evidence concerns the gene TRAF3 and colorectal carcinoma.