To confirm whether the activation of noncanonical NF‐κB depends on the repression of TRAF3 induced by miR‐361‐3p, we observed whether the overexpression levels of NIK and p52 in CRC cells induced by upregulated miR‐361‐3p were replicated in the TRAF3 knockdown group. The gene discussed is NFKB1; the disease is colorectal carcinoma.