Other AE types with ≥grade 3 events included atrial fibrillation (one grade 3 event), heart failure (three grade 4 events), fever (six grade 3 events), increased alanine aminotransferase (three grade 3 events), increased aspartate aminotransferase (one grade 3 event), increased blood bilirubin (one grade 3 events), prolonged QT interval (one grade 3 event), increased creatinine (one grade 3 event), neutropenia (three grade 3 and 26 grade 4 events), thrombocytopenia (three grade 3 and 21 grade 4 events), leukopenia (three grade 3 and 26 grade 4 events), and hyponatremia (one grade 3 event). The gene discussed is GPT; the disease is heart failure.