revealed another mechanism: overexpression of SLC39A4 increases the transcription of interleukin 6 (IL‐6) through cAMP response element‐binding protein (CREB), which activates signal transducer and activator of transcription 3 (STAT3) and increases the expression of cyclin D1 to increase cell proliferation and tumor progression in pancreatic cancer.33 This evidence concerns the gene CREB1 and pancreatic neoplasm.