BCL2L1 and familial pancreatic carcinoma: also found that use of the zinc chelator N,N,N',N'‐tetrakis (2‐pyridylmethyl) ethylenediamine (TPEN) to deplete cellular zinc levels induced pancreatic cancer cell apoptosis by regulating the expression of mitochondria‐related genes in the Bcl family (Bcl‐X, Bcl‐2, Bcl‐W, and Bcl‐XL), and this effect was reversed by zinc addition.57