reported that the physiological zinc level exerts cytotoxic effects on pancreatic cancer cells and that the downregulation of Ras responsive element‐binding protein 1 (RREB1) represses the expression of SLC39A3, resulting in a decrease in zinc levels, which alleviates these cytotoxic effects and promotes the proliferation of pancreatic cancer cells.43, 44. This evidence concerns the gene RREB1 and familial pancreatic carcinoma.