Recent studies suggested that the expression of pluripotency factors, including NANOG, SRY‐box transcription factor 2 (SOX2), Kruppel like factor 4 (KLF4), and POU class 5 homeobox 1 (OCT4), could induce HCC cells reprogramming and self‐renewal as in the case of induced pluripotent stem cells.8, 9, 10. Here, NANOG is linked to hepatocellular carcinoma.