Following 6 weeks of TAC surgery, VEGFR‐3f/f mice showed characteristics of HF, as indicated by significant decreases in FS%, left ventricular anterior wall (LVAW) and left ventricular posterior wall (LVPW) thickness and an increase in LVID, which was further aggravated in VEGFR‐3f/− mice (Figure 3A, supplementary material online, Table S4). This evidence concerns the gene KDR and hydrops fetalis.