We found that there were similar expression patterns between Tbx1 and VEGF‐C or VEGFR‐3 during the transition from adaptive cardiac hypertrophy to TAC‐induced HF (supplementary material online, Figure S4C), suggesting that Tbx1 may be involved in regulating VEGF‐C or VEGFR‐3 expression in the heart. This evidence concerns the gene VEGFC and persistent truncus arteriosus.