TAMs are recruited by different chemokines and cytokines such as chemokine (C-C motif) ligand 2 (CCL2), CCL5, CCL7, angiopoietin-2 (Ang-2), CSF1, VEGF, IL-33, semaphorin 3D, endothelial monocyte–activating polypeptide-II (EMAP-II), endothelin (ET)-1 and 2, stromal cell–derived factor 1α (SDF1α/CXCL12), eotaxin, and oncostatin which are secreted by cancer cells, stromal cells, and perivascular and vascular cells. This evidence concerns the gene EDN1 and cancer.