More related to this review, the combination of Ang-2 and VEGF inhibition induces the normalization of the tumor vasculature and promotes TAM reprogramming from M2 toward M1 phenotype and hence increases the M1/M2 ratio and the overall survival in sarcoma and GBM murine models [81, 213, 214]. The gene discussed is ANGPT2; the disease is neoplasm.