Once in the tumor, TAMs secrete pro-angiogenic factors such as VEGF-A, TGF-β, fibroblast growth factor-2 (FGF-2), CCL18, semaphorin 4D (Sema4D), adrenomedullin (ADM), and placental growth factor (PlGF) [128–133]. The gene discussed is SEMA4D; the disease is neoplasm.