BBC3 and neuroblastoma: During activation by ER stress, PUMA expression is regulated by IRE1-JNK-c-jun [59, 67], the ATF4-CHOP-PUMA signaling axis [97], and the P38-PUMA-BAX pathway, induced by 6-hydroxydopamine (6-OHDA) in PD and the subsequent activation of caspase -3 and cytochrome c release in SH-SY5Y neuroblastoma cells [60].