PUMA is partially controlled by P53, including the P53 transcriptional pathway in CA1 subregion neurons [102], P53-mediated cell death in a PD model [103], P53 and ERK1/2 pathways in SH-SY5Y neuroblastoma cells [65], and the NF-κB-P53-PUMA pathway in the rat hippocampus [61]. The gene discussed is TP53; the disease is neuroblastoma.