In addition, PUMA upregulation is dependent on ROS through the signaling cascade—ROS-JNK-P53-PUMA-caspase–3 and PI3K-AKT-FOXO3a-PUMA, which facilitates the occurrence and progress of Alzheimer’s disease (AD) [32]. This evidence concerns the gene BBC3 and early-onset autosomal dominant Alzheimer disease.