PUMA induces mitochondrial ROS generation through functional BAX, irrespective of their P53 status, and it activates nuclear factor erythroid 2-related factor 2 pathway [89], which in turn results in DNA damage response, including ATM, ATR, DNA-PKcs, CHK1, and CHK2, along with JNK activation, finally producing apoptosis in ovarian cancer cells [89]. This evidence concerns the gene MAPK8 and ovarian carcinoma.