SLC4A1 and metabolic syndrome: Interestingly, querying the WD1 and WD5 DEGs against the molecular signature database collection of curated gene pathway annotations revealed a specific WD5 enrichment in gene sets associated with CHEN_METABOLIC_SYNDROM_NETWORK (genes forming the macrophage-enriched metabolic network claimed to have a causal relationship with metabolic syndrome traits) and with genes potentially regulated by the methylation of lysine 4 (H3K4) and lysine 27 (H3K27) of histone H3 and by polycomb repressive complex 2 (PRC2) (Figure 1—source data 2; Liberzon, 2014).