Mizutani et al. reported that the expression of some ESRP-target exons was related with good prognosis in ccRCC and with the expression of RNF111, a molecular which interacted with ESRP2, induced polyubiquitination and suppressed ccRCC tumor growth in a coordinated manner [52]. This evidence concerns the gene RNF111 and nonpapillary renal cell carcinoma.