CXCL9 and neoplasm: Indeed, a 2019 publication reported that the cooperation of chemokines such as chemokine ligand 5 (CCL5), which is constitutively expressed by tumour cells, with IFN-γ-inducible chemokines such as chemokine ligand 9 (CXCL9), plays a key and universal role in the orchestration of T-cell responses in tumours and facilitates the establishment of the T-cell-inflamed phenotype.175 The loss of tumour-intrinsic chemokines (such as CCL5, for example) that support T-cell recruitment is a common mechanism of immunoevasion.