We included the 8 mutational signatures previously identified in MM: SBS1 and SBS5, mutations related to the cell aging (i.e., clock-like); SBS2 and SBS13, resulting from APOBEC cytidine deaminase activity; SBS9, attributed to the non-canonical genome-wide action of AID (nc-AID); SBS8 of unknown etiology; SBS18, which may be related to DNA damage from reactive oxygen species; and SBS-MM1, the mutational footprint of melphalan therapy (Fig. 1B)11. The gene discussed is CDA; the disease is Miyoshi myopathy.