Although, breeds like Bangledeshi, Castellana, Changthangi, Dorper, Eastern Tibetan, Garole, Santa Inês, Sumatra, and, White Dorper may provide a potential source for TLR2 Q650 alleles, it is unknown whether haplotypes “13”, “15”, and “17” are associated with reduced susceptibility to OJD in those breeds, and whether other haplotypes containing Q650 (e.g., “3”, “10”, and “11”) are also associated with infection. Here, TLR2 is linked to infection.