NOSIP and osteoporosis: According to model 1, the honeydew module had 31 genes significantly and jointly associated with early traits of both osteoporosis (DRToBMC) and atherosclerosis (BIMTmax) (Table S8), the most significant (p.adj = 7.4 × 10−16) being Nitric Oxide Synthase Interacting Protein (NOSIP) (Table 4).