MTHFD2 and cancer: In addition, PD-L1 mRNA (Fig. 6g) and protein (Fig. 6h), as well as both O-GlcNAcylated and total cMYC proteins (Fig. 6h), were suppressed by MTHFD2-KD and recovered by exogenous UTP/UDP in cMYC-overexpressing cancer cells, all of which were compromised in MYC-T58A-overexpressing cells.