The high expression of LMNB2 protein was positively correlated with tumor diameter (P < 0.001), TNM stage (P < 0.001), lymph node metastasis (P = 0.003), distant metastasis (P = 0.039), and depth of invasion (P = 0.015). This evidence concerns the gene LMNB2 and metastatic malignant neoplasm in the lymph nodes.