NPM1 and acute myeloid leukemia: In this study, we show that NPM1c+ deregulates its signature genes, perturbs hematopoiesis, and promotes leukemogenesis via the activation of a critical lncRNA, HOXBLINC. HOXBLINC overexpression is strongly associated with NPM1 mutations in AML and NPM1c+ expression leads to HoxBlinc activation in HSPCs.