When the RNA-seq data from TCGA-LAML datasets consisting of a cohort of 181 AML patients was analyzed for HOXBLINC expression, significantly higher HOXBLINC expression was observed in NPM1c+, but not MLL-rearranged (MLLr+) AML patients as compared to NPM1c−MLLr− patients (Fig. 1b). This evidence concerns the gene KMT2A and acute myeloid leukemia.