GSEA and GO analyses revealed that loss of HOXBLINC affects the pathways and genes involved in AML with NPM1-mutated, HOXA9 pathway, pathways in cancer, cell cycle, cell fate commitment, myeloid cell differentiation, and Wnt and JAK-STAT signaling pathways (Fig. 1e, f; Supplementary Fig. 2b), similar to those observed in the upregulated genes of Npm1c/+ vs. WT LSK cells (Supplementary Fig. 1f, g). Here, NPM1 is linked to acute myeloid leukemia.