NPM1 and cancer: Gene Ontology (GO) and gene set enrichment (GSEA) analyses revealed that the upregulated genes in Npm1c/+ vs. WT LSK cells are enriched with cell fate commitment, cell cycle, myeloid cell proliferation, stem cell maintenance, Wnt and Jak-STAT signaling pathways, pathways in cancer, as well as AML NPM1-mutated and HOXA9 oncogenic pathway (Supplementary Fig. 1f, g).