Consistently, HOXBLINC was highly expressed in NPM1c+ OCI-AML3 and IMS-M2 AML cells, but not NPM1-wt AML cells such as MLLr+ MOLM-13, MV4-11, THP-1, NOMO-1, and OCI-AML2 cells, as well as BCR-ABL1+ K562 and JAK2V617F+ SET-2 cells (Supplementary Fig. 1c). Here, RUNX2 is linked to acute myeloid leukemia.