The critical roles of PRMT4, PRMT5, PRMT7, and hnRNPA1 in cell growth were also demonstrated in HCT 116 cells (Supplementary Fig. 7a, b), a colon cancer cell line, and LNCaP (Supplementary Fig. 7c, d), a prostate cancer cell line. This evidence concerns the gene PRMT5 and Familial prostate cancer.