PRMT5 and herpes simplex infectious disease: Comparison among the PRMT4, PRMT5, and PRMT7 methylomes revealed that the substrates of PRMT4 and PRMT5 were also implicated in pathways similar to PRMT7, such as spliceosome, RNA transport, mRNA surveillance pathway, and herpes simplex infection, suggesting that proteins in these pathways are hotspots for PRMT targets.