Along with high levels of methylation of PRMT4, PRMT5, PRMT7, and hnRNPA1 in tumor samples, changes in gene alternative splicing were observed, such as those for PPARA, SREBF2, RAB27B, and WDPCP in BRCA, CRC, and PC samples (Fig. 6e–g and Supplementary Fig. 6a–c). Here, HNRNPA1 is linked to pachyonychia congenita.