Compared with the normal pancreatic ductal epithelial cell line HPDE6-C7, ATF4 was significantly upregulated in pancreatic cancer cell lines such as PANC-1, BxPC-3, CFPAC-1, MIA PaCa-2, and SW1990 (Fig. 1D, E). The gene discussed is ATF4; the disease is familial pancreatic carcinoma.