Similar to the SAMs, the TAMs in the primary tumor separated into two populations: one with high expression of Chil3, Plac8, and Ly6c2 (Chil-TAMs), and the other with high expression of C1qa, C1qb, and Trem2 (Cq-TAMs) (Fig 4D). This evidence concerns the gene PLAC8 and neoplasm.