PDX1 and pancreatic neoplasm: We used an orthotopic syngeneic model using 7940b cells (Long et al, 2016; Zhang et al, 2017), derived from a pure C57BL/6J (BL/6) version of the LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx1-Cre (KPC) genetically engineered mouse model of pancreatic cancer (Hingorani et al, 2005).