We used a published dataset of single-cell RNA sequencing on PBMCs from healthy donors (n = 4) and PDA patients (n = 16) (Steele et al, 2020) and queried it for the expression of our signature genes: C1QA, C1QB, and TREM2 (Fig S8A). The gene discussed is C1QA; the disease is Patent ductus arteriosus.