To assess the expression of TREM2, C1QA, and C1QB, and PLAC8 we queried a single-cell RNA sequencing dataset including human normal/adjacent normal pancreas (n = 3) and human PDA tumors (n = 16) (Steele et al, 2020) (Fig 6A). This evidence concerns the gene PLAC8 and Patent ductus arteriosus.