Zhang et al (2019) reported that TAMs help tumor cells avoid complement-mediated cell death, providing mechanistic insight into TAM and complement component cross-talk in pancreatic cancer (Zhang et al, 2019). Our data provide evidence for up-regulation of the complement components C1QA and C1QB in PDA TAMs systemically. Further work is needed to determine if the up-regulation of complement components is a side effect of the systemic inflammation caused by PDA or if it is functionally contributing to carcinogenesis (Bettac et al, 2017). This evidence concerns the gene C1QB and familial pancreatic carcinoma.