Tumor-bearing scaffolds had lower expression of interferon γ (Ifng) and killer cell lectin like receptor G1 (Klrg1), markers of T-cell activation/effector T cells, and, conversely, up-regulation of coagulation factor II thrombin receptor (F2r), a marker of exhausted T cells (Wherry et al, 2007) (Fig 2B). Here, F2R is linked to neoplasm.