SYNPO and early-onset autosomal dominant Alzheimer disease: Accordingly, alterations in synaptopodin expression and retinoid signaling have been observed in the brain tissue of patients with Alzheimer’s disease and cognitive decline (Goodman, 2006; Goodman and Pardee, 2003; Mingaud et al., 2008; Misner et al., 2001; Reddy et al., 2005).