Fostamatinib (R788) successfully ameliorated lupus-like disease in the New Zealand black/white (NZB/W) [26] and Murphy Roths Large/lymphoproliferation (MRL/lpr) [27] preclinical mouse models of SLE and LN, although the inhibitor is nonselective and it is unclear if the activity can be solely attributed to inhibition of SYK activity [28]. Here, SYK is linked to lobular neoplasia.