NAGA and PRNP are associated with Kanzaki disease/Schindler disease type II and prion diseases, respectively, all of which have neurologic manifestations occurring mainly in adulthood and for which there are no effective interventions that can improve or prevent symptoms of disease though potential therapies are being studied [42, 43]. This evidence concerns the gene PRNP and alpha-N-acetylgalactosaminidase deficiency type 2.