The three common mutant sitesmt.3460, mt.11778 and mt.14484were found to be the main (96%) causes of LHON, with MTND4 m.11778G > A being the most common pathogenic mutation, followed by MTND6 m.14484 T > C and MTND1 m.3460G > A. This evidence concerns the gene MT-ND1 and Leber hereditary optic neuropathy.