In our present study, we found that after the construction of obesity-induced IR animal model, in total CD4+ T cells, Treg cells were reduced, Th17 cells were increased, levels of markers TGF-β1 and IL-10 were downregulated, and those of IL-17 and IL-6 were upregulated. This evidence concerns the gene TGFB1 and obesity due to melanocortin 4 receptor deficiency.