Upregulating miR-23b-3p further enhanced the effects of obesity-induced IR on downregulating TGF-β1 and IL-10 protein expressions and upregulating IL-17 and IL-6 expressions (Fig. 3e-f, P < 0.001 and additional file 1). The gene discussed is IL10; the disease is obesity due to melanocortin 4 receptor deficiency.