Whole transcriptome/exome sequencing and fluorescence in situ hybridization (FISH) analysis of Ph-like B-ALL samples revealed high frequency of genomic alterations disrupting the normal function of kinase and cytokine receptor signaling pathways of which ABL-class kinase and JAK-STAT signaling pathway genes were the most commonly affected [6]. The gene discussed is SOAT1; the disease is acute lymphoblastic leukemia.