Gene expression profiling (GEP) of patients negative for canonical B-ALL alterations identified a subgroup of cases characterized by a similar expression profile to those harboring t(9;22) (q34;q11)/BCR-ABL1 (Philadelphia chromosome-like (Ph-like) or BCR-ABL1-like B-ALL) [4, 5]. This evidence concerns the gene BCR and acute lymphoblastic leukemia.