CD4 and neoplasm: Although DMHCA did not reduce the primary population of circulating Treg cells (CD4+/Foxp3+/PD-1-) [52], it did reduce the percentages of both M-MDSC and G-MDSC in tumor infiltrates (Fig 5A) and G-MDSC in the spleen (Fig 5B) and increased the percentages of macrophages and dendritic cells in the spleen (Fig 5B), but not in the tumor.