The major transcriptional effects of DMHCA were linked to transrepression of a network of LXR-responsive genes, including PTGS2, S100A9, SPP1, CD14, CCL5 and ANXA1, which are overexpressed in MDSC [57–62] and in a significant proportion of breast cancers [63], where they denote poor survival [57]. Here, SPP1 is linked to breast carcinoma.