In hormone receptor-negative breast cancer, the repertoire of stromal cells in the TME [4, 7, 8] produces fibrotic foci and earlier invasion [9], which elicit the secretion of inflammatory factors that contribute to immune suppression in multiple ways [4, 10, 11], including the secretion of a dense fibrotic collagen matrix that impedes the penetration of cytotoxic CD8+ effector T cells (CTL) into the tumor [12]. This evidence concerns the gene CD8A and neoplasm.