GATA1 and acute megakaryoblastic leukemia: Meta-analyses of clinical reports of TAM and DS-AMKL [7, 10–14] and a case report of monozygotic twins [2, 13, 15, 16] have shown that almost all TAM and DS-AMKL cases have somatic mutations of GATA-binding protein 1 (GATA1) gene and that these mutations are essential in the multi-step development process of DS-AMKL.