Furthermore, the phosphorylation of the CD44 intracellular domain can directly trigger intracellular signaling, particularly tyrosine kinase, including the Akt protein, for supporting growth, motility and invasion in many types of cancer [18], including breast [30, 31], prostate [32], and colon cancers [33]. The gene discussed is AKT1; the disease is malignant colon neoplasm.