Particularly, the role of the liver as a reservoir of pluripotent stem cells, which give rise to multiple cell lineages, including NKT [12, 13] and Cd8+ T cells [14], and the adaptive immune response during chronic non-alcoholic fatty liver disease (NAFLD) has been the focus of recent research as reviewed [15]. This evidence concerns the gene CD8A and metabolic dysfunction-associated steatotic liver disease.