NOTCH2 and cancer: Interestingly, the chromosomal regions among CYT-low skin melanomas that harbored chromothripsis, contained a higher number of cancer genes, including KRAS, NOTCH2, BCL9, CCND1 (gains) and BRAF, NRAS, PAX3, ATM and CD274 (losses) (in total, 306 gains and 209 losses among CYT-low tumors vs. a total of 156 gains and 75 losses among CYT-high tumors) (Fig. 5b and Table S4).