On the other hand CYT-low metastatic melanomas had recurrent amplifications in loci 5p15.33 (TERT), 6p25.1 (CDYL), 7p22.2 (RAC1), 12q15 (MDM1) and recurrent deletions in 5q31.2 (CTNNA1, FGF1), 11q22.3 (FDX1, RDX, ZC3H12C), and 15q14 (RASGRP1, CSNK1A1P1, SPRED1). The gene discussed is RASGRP1; the disease is melanoma.