Many of them were previously appreciated in the genome of skin melanomas (e.g., MITF, NOTCH2, PD-L1 and JAK2 amplifications, or CDKN2A deletions [3]); however, the CNAs in genomic locations harboring PAX5, ETS1, BCL7, RAD51, APAF1, FOXO3 and CTNNA1 are novel. The gene discussed is APAF1; the disease is cutaneous melanoma.