Hypothesizing that CYT-high skin melanomas have higher immunophenoscore due to increased immunogenicity, which in turn results in better prognosis and response to therapy, we analyzed two data sets containing skin melanoma patients, who, if treated with anti-CTLA-4 and/or anti-PD-1 inhibitory molecules, we could use their IPS to predict their clinical response. Here, PDCD1 is linked to cutaneous melanoma.