While the density of IBA1+ microglia in MS cortex was variable and not significantly different from controls (Fig. 1c), morphological analysis of a large number of individually traced microglia revealed a more ramified microglia morphology in MS cortex, as indicated by the area under the curve (AUC) of the Sholl analysis [17] (Fig. 1d, e). Here, AIF1 is linked to myeloid sarcoma.