Histologic significance: Unlike PLGNTs with KIAA1549-BRAF fusions, tumors with BRAF p.V600E SNVs are histologically diverse, with this mutation occurring in up to 80% of pleomorphic xanthoastrocytoma (PXAs), 40% of PDLGGs, and 45% of GGs (Fig. 5) [25]. The gene discussed is BRAF; the disease is pleomorphic xanthoastrocytoma.