TSPO and Alzheimer disease: In a non-TSPO brain PET study with 11C-PIB [47], the kinetic classes were defined from a dataset of healthy individuals and patients with Alzheimer’s disease acquired with ECAT EXACT HR+ (CTI/Siemens) [29] and then applied to an independent dataset of healthy volunteers and patients with multiple sclerosis acquired with a Siemens HRRT.