Using both of these approaches, we found that respiratory rate, lactate, blood pressure (systolic and diastolic), hemoglobin, hematocrit, venous and arterial base excess, neutrophils, albumin, urea, platelet count, and potassium were good indicators of the patients’ disease severity and represented a small set of predictors of COVID-19 severity measurements. The gene discussed is ALB; the disease is COVID-19.