Specifically, S. aureus AdsA, together with a secreted nuclease (Nuc), converts neutrophil extracellular DNA traps (NETs) into deoxyadenosine (dAdo), which is cytotoxic for macrophages and other immune cells thereby supporting staphylococcal persistence in deep-seated abscess lesions and dissemination of disease [27–29]. The gene discussed is RNF170; the disease is abscess.