NUCB1 and bacterial infectious disease with sepsis: Interestingly, some of these species (i.e., Staphylococcus intermedius, Staphylococcus cornubiensis, or Staphylococcus delphini) can cause abscesses, wound infections, or bacteremia in humans raising the possibility that these bacteria may also use a Nuc/AdsA signaling cascade to perturb host immune cell assemblies during pathogenesis [51–54].