Among 83 lipids significantly altered in patients compared with healthy controls, 2 lipids were also correlated with serum VEGF levels serum of 24 patients with POEMS syndrome: prenol lipid 31‐hydroxy‐32,35‐anhydrobacteriohopanetetrol (r=−0.489, P =.015) and sphingolipid Cer(d18:0/13:0) (r=−0.465, P =.022). This evidence concerns the gene VEGFA and POEMS syndrome.