Here, we explore some of the top ranked TRs including histone deacetylase 2 (HDAC2), estrogen receptor 1 (ESR1), TEA domain family member 4 (TEAD4), achaete-scute homolog 1 (ASCL1), androgen receptor (AR) and yes associated protein 1 (YAP1) in several cancer types. The gene discussed is AR; the disease is cancer.