Here we highlight six factors from the top three ranked TRs predicted from the down-regulated genes in several cancer types: GATA-binding protein 4 (GATA4), repressor element 1 (RE-1)-silencing transcription factor (REST), forkhead box A1 (FOXA1), ESR1, hepatocyte nuclear factor 4 alpha (HNF4A) and AR. The gene discussed is HNF4A; the disease is cancer.