WNT16 and osteoporosis: Taken together, our data suggest that Wnt16 promotes optimal bone repair postfracture by regulating osteoblast differentiation and bone matrix synthesis via the regulation of canonical Wnt activity and runx2a. This highlights the modulation of the canonical Wnt pathway and WNT16 as potential osteo‐anabolic candidates for further exploration in osteoporosis therapy development.