HNF4A and osteoporosis: Disordered activation of the canonical Wnt signaling pathway has been linked to the pathogeneses of many age‐related diseases, including osteoporosis.(8) Canonical Wnt signaling culminates in the accumulation of β‐catenin in the cell, which translocates to the nucleus where it binds to and activates the transcription factors, TCF/LEF (T‐cell factor/lymphoid–enhancing binding factor).