SIRT1 and cancer: Resveratrol diminishes cellular stresses including inflammation, oxidative stress, and blocked autophagy, resulting in anti‐aging, anti‐cancer, neuroprotective, anti‐diabetic, and cardioprotective properties.(57, 58, 59, 60, 61, 62) Resveratrol promoted autophagy in the mutant‐COMP pathology by upregulating SIRT1, which increased the number of LC3‐positive autophagosomes (Figs. 1 and 4B).