SPP1 and osteoporosis: Interestingly, in a study of human osteoclasts, cyanoamino acid metabolism expression was downregulated in samples treated with bisphosphonates, drugs commonly used to treat osteoporosis by inhibiting bone resorption.(68) In a glucocorticoid‐induced osteoporosis rat model, cyanoamino acid metabolism was identified as a potential biomarker for osteoporosis using metabolomics.(69) This finding aligns with our results in which cyanoamino acid metabolism was higher in OP and OPN participants.