Third, consistent with the in vitro role of PLK4 in a myofibroblast-like cell-type transition, PLK4 inhibition mitigates vascular fibrosis in vivo, implicating a new antifibrotic strategy.PerspectivesCOMPETENCY IN MEDICAL KNOWLEDGE: Fibrosis can occur in essentially every organ, leading to a wide spectrum of pathologies, including cardiovascular diseases. This evidence concerns the gene PLK4 and fibrosis.