In this study, we first examined the expression of CLL-1 in samples of newly diagnosed or relapsed/refractory AML patients and compared it with other classic markers in AML, in order to assess the value of CLL-1 as an independent biomarker or in combination with other markers for diagnosis in AML and subsequently assessed the value of CLL-1 as a biomarker for prognosis in this malignant tumor. The gene discussed is CLEC12A; the disease is neoplasm.