Upregulated DEGs were mainly enriched in CH-related pathways (Figure 1(b) and 1(c)), such as PI3K-Akt signaling pathway, ECM-receptor interaction, regulation of actin cytoskeleton, hypertrophic cardiomyopathy (HCM), and cytokine-cytokine receptor interactions. Here, AKT1 is linked to cyclic hematopoiesis.