It was demonstrated that the cross-sectional area in the TAC group was significantly higher than that in the Sham group, accompanying the activation of PI3K-Akt signaling pathway, resulting from the level of phosphorylated PI3K, AKT, GSK3β, mTOR, P70S6K, and eIF-4E. The gene discussed is RPS6KB1; the disease is persistent truncus arteriosus.