LGALS3 and tumor of parathyroid gland: However, an interesting study involving parathyroid-specific Cdc73-knockout mice—in which one or both Cdc73 alleles were deleted, resulting in the development of parathyroid tumors—revealed nuclear pleomorphism, fibrous septa, and overexpression of galectin-3 in 75% of patients, consistent with the histological diagnosis of AA.