The patient with MEN1 syndrome (ID 039, Table 2) harbored two alterations in CDC73. Three types of EZH2 alterations (c.647G>A: p.Arg216Gln, c.1451C>A: p.Pro484Gln, and c.1936T>A: p.Tyr646Asn) were detected in four AA samples, and Tyr646Asn was recurrently identified in two patients with AA. Here, EZH2 is linked to multiple endocrine neoplasia type 1.