The following parameters were significantly associated with big ET-1 level on admission: etiology (r = 0.086, p = 0.019), SBP (r = −0.088, p = 0.016), arterial pH (r = 0.102, p = 0.006), lactic acid (r = 0.145, p = 0.001), serum sodium (r = −0.112, p = 0.002), Hb (r = −0.146, p < 0.001), albumin (r = −0.097, p = 0.008), TBIL (r = 0.354, p < 0.001), Scr (r = 0.246, p < 0.001), SUA (r = 0.336, p < 0.001), eGFR (r = −0.124, p = 0.001), NT-proBNP (r = 0.438, p < 0.001) and presence of AF (r= −0.152, p < 0.001). Here, EDN1 is linked to atrial fibrillation.