AR and Familial prostate cancer: Androgen receptor (AR) is an important target for many diseases including prostate cancer, hypogonadism, muscle wasting, osteoporosis, and benign prostate hyperplasia (Chen et al., 2004; Gao and Dalton, 2007; Dillon et al., 2010; Tan et al., 2015; Li et al., 2019).