sEH inhibition prevents cardiac hypertrophy in experimental models based on angiotensin II infusion (Ai et al., 2009), aortic banding (Xu et al., 2006), renovascular hypertension (two kidney one clip) (Gao et al., 2011; Wang Z. H. et al., 2013) and metabolic disease related to obesity and insulin resistance (Roche et al., 2015a). This evidence concerns the gene EPHX2 and obesity due to melanocortin 4 receptor deficiency.