EPHX2 and cardiovascular disorder: In human, genetic polymorphisms of EPHX2, which encodes sEH, could either increase hydrolase activity which is associated with a higher occurrence of ischemic cardiac events (Lee et al., 2006), or decrease its activity associated with higher endothelium-dependant dilatation in resistance arteries (Lee et al., 2011), strengthening the interest of inhibiting sEH in cardiovascular diseases.