In our study, we predicted a binding relationship between C/EBPβ and the promoter region of HAS2-AS1 using bioinformatic analysis and explore the influence on proliferation, migration, and inflammation of human fetal lung fibroblast-1 (HFL-1) cells, which provided a potential novel target for the treatment of HPH associated with IPF. The gene discussed is CEBPB; the disease is idiopathic pulmonary fibrosis.